Neuromuscular junction symposium

Neuromuscular Junction Effects Does Pb Produce Neuromuscular Junction Changes?

Acetylcholinesterase (AChE) inhibitors, including PB, produce acute destructive changes at the neuromuscular junction, the site of connection between nerve cells and muscle fibers, at which nerve cells signal muscles to contract. Because studies of the neuromuscular junction require microscopic inspection of muscle tissue and tests of electrical and chemical properties of the neuromuscular junc...

The neuromuscular junction disorders.

Neuromuscular junction (NMJ) disorders result from destruction, malfunction or absence of one or more key proteins involved in neuromuscular transmission, illustrated diagrammatically in fig 1. The most common pathology is antibody mediated damage or down regulation of ion channels or receptors, resulting in myasthenia gravis (MG), Lambert-Eaton myasthenic syndrome (LEMS), and acquired neuromyo...

SnapShot: Neuromuscular Junction

The Neuromuscular Junction

If such a nerve fiberwere to be directly joined to amuscle fiber of, say, 50μmin diameter, then as the propagating action potential reached the nerve–muscle junction, the local circuit current density set up in the muscle would be considerably reduced from that in the nerve. This reduction would occur because the nerve and muscle must have the same total current, a consequence of current conser...

Pathology of the neuromuscular junction.

Diagnosis of neuromuscular disease by the study of motor endplate structure in the light and electron microscopes is probably one of the most specialized examinations in the field of neuropathology. The classical means of staining endplates using gold, silver or methylene blue are described as well as more modern techniques suitable for light microscopy. Specific abnormalities in patterns of te...